Preheat oven temperature to 350 degrees F.
Whisk eggs Cream, milk ingredients in medium bowl.
Whisk pumpkin puree, sugar, flour, and spice in another medium bowl.
Add egg to the mixture and whisk until well blended. Pour filling into crust.
Bake pie until filling is puffed around the edges andthe center moves slightly when pan is shaken,about 1 hour and 5 minutes.
Cool on a rack.Chill until cold at least 4 hours or overnight.